General Information

  • ID:  hor006032
  • Uniprot ID:  Q29KK2
  • Protein name:  sNPF-associated peptide
  • Gene name:  sNPF
  • Organism:  Drosophila pseudoobscura pseudoobscura (Fruit fly)
  • Family:  NPY family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Drosophila pseudoobscura (species), pseudoobscura subgroup , obscura group , Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae , Schizophora , Cyclorrhapha , Eremoneura , Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta (class), Hexapoda (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0032095 regulation of response to food; GO:0040014 regulation of multicellular organism growth
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SDPDMLNNIVE
  • Length:  11
  • Propeptide:  MFRFNPQLSHGCALALICCLLNLLMMHQPTNAELSPVVQGEFFLPILPDDHPPNTDTSFGGPISNLYDNLLQREYAGPVVFPNHQVERKAQRSPSLRLRFGRSDPDMLNNIVEKRWFGDVNQKPIRSPSLRLRFGRRDPTLPQMRRTAYDDLLERELTLNNQQQQQLGDTADDLSADYDGLYERVVRKPQRLRWGRSVPQFEATIGDNDQLYNSLWNSEKMRRMLLALQQYEAAPGHVAGYANDGDDTEAQLDEDTSEFQREARKPMRLRWGRSTGKAPQIETSSIAPKN
  • Signal peptide:  MFRFNPQLSHGCALALICCLLNLLMMHQPTNA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a role in controlling food intake and regulating body size.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q29KK2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006032_AF2.pdbhor006032_ESM.pdb

Physical Information

Mass: 142491 Formula: C51H83N13O21S
Absent amino acids: ACFGHKQRTWY Common amino acids: DN
pI: 3.38 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -50 Boman Index: -2470
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 97.27
Instability Index: 3446.36 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15632085
  • Title:  Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.